Team

–  Principal Investigator:

Francisco Bozinovic

– Associate Researchers: 

Pablo Sabat

Roberto Nespolo

– Postdoctoral associates: 

– Professionals and technicians:

José Miguel Bogdanovich

– Graduate students

Doctorate:

Research:

My research interests cover a broad range of topics, but I am mostly engaged in ecological physiology with strong ties into behavioral ecology, evolutionary ecology and biogeography. In my opinion, an understanding of the processes underlying global ecological and evolutionary patterns can only be achieved by an integration of these disciplines. Hence, physiological mechanisms and tolerances, ecological and evolutionary constraints all contribute, depending on the taxon and scale of study, to the distribution, abundance and success of species and populations. I have long studied the impact of environmental changes on intergative physiology, with the primary goal of determining and assessing the proximate abiotic and biotic factors that might impact the Darwinian fitness. In my opinion, this endeavor is becoming increasingly important due to the accelerating rate of human-induced environmental perturbations.

Objectives:

Study organismic responses to the impact of global change

Integrate aspects of physiology biodiversity management

Use new tools (genomics , molecular biology , toxicology ) to understand and predict the impact of environmental change on biodiversity

Actual research lines:

We investigate (eg, metabolic, thermoregulation, digestive, osmotic, immunological, neuronal) physiological limitations on biodiversity, in order to improve the ability to predict responses of organisms to environmental perturbations, such as climate change, disease and habitat loss. In our opinion, by understanding the underlying mechanistic basis of the capabilities of the body to respond to biotic and abiotic environment, a solid foundation can be built to develop predictions about the likelihood of success or failure of individuals, populations and species (including invasive species and crops or human beings) to deal with the global changes that are coming. As integrative biologist, working with invertebrates (eg piriwinkles, mussels, insects and woodlices) and vertebrates (eg fish, amphibians, lizards, birds and mammals).

Projections and challenges:

Deliver explanations and transfer knowledge to society and proposals on the impacts and responses of organisms to environmental changes

Publicaciones: 

2014

1) Bozinovic F, Ferri-Yánez F, Naya H, Araújo MB & Naya DE (2014) Thermal tolerance in rodents: species that evolved in cold climates exhibit a wider thermoneutral zone. Evolutionary Ecology Research 16: 000-000. PDF: Bozinovic et al. 2014_Evol Ecol Res

2) Bozinovic F, Orellana MJM, Martel SI, Bogdanovich JM (2014) Testing the heat-invariant and cold-variability tolerance hypotheses across geographic gradients. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 178:46-50. doi: 10.1016/j.cbpa.2014.08.009. PDF: Bozinovic et al. 2014_Comparative Biochem

3) Clavijo-Baquet S, Boher F, Ziegler L, Martel SI, Estay SA & Bozinovic F (2014) Differential responses to thermal variation between fitness metrics.  Scientific Reports 4: 5349. doi:10.1038/srep05349. PDF: Clavijo-Baquet_ Sci Reports_2014

4) Estay SA, M Lima& F Bozinovic (2014) The role of temperature variability on insect performance and population dynamics in a  warming world. Oikos 123:131-140. PDF: Estay et al (2014) Oikos Thermal Variability_2014

5) González-Gómez PL, Suarez R, Madrid N, Vásquez RA & Bozinovic F (2014) Cognitive ecology in hummingbirds: the role of sexual dimorphism and its anatomical correlates on memory. PLoS One9(3): e90165. PDF: Gonzalez-Gomez et al. PLOS one 2014

6) Martel SI, SA Riquelme, AM Kalergis & F Bozinovic (2014) Dietary effect on immunological energetics in mice. Journal of Comparative Physiology B 184(7):937-944. PDF: Martel et al. 2014

7) Nuñez-Villegas M, F Bozinovic & P Sabat (2014) Interplay between group size, huddling behavior and basal metabolism: an experimental approach in the social degus. Journal of Experimental Biology 217:997-1002. PDF: Nuñez-Villegas et al. J Exp Biol-2014

8) Peña-Villalobos I, M Nuñez-Villegas, F Bozinovic & P Sabat (2014) Metabolic enzymes in seasonally acclimatized and cold acclimated Rufous-collared sparrow inhabiting a Chilean Mediterranean environment. Current Zoology 60:338-350. PDF: Peña-Villalobos_2014

9) Ríos JM, Barceló GF, Narvaez C, Maldonado K & P Sabat (2014) Feeding and digestive responses to fatty acid intake in two South  American passerines with different food habits. Journal of Comparative Physiology B, DOI 10.1007/s00360-014-0832-1. PDF: Rios et al (JCPB 2014)

10) Rojas JM, SB Castillo, G Folguera, S Abades & F Bozinovic (2014) Coping with daily thermal variability: behavioral performance of an ectotherm model in a warming world. PLoS One DOI: 10.1371/journal.pone.0106897. PDF: Rojas et al. 2014

11) Sánchez-Hernández JC, Narvaez C, Sabat P & S Martínez (2014) Integrated biomarker analysis of chlorpyrifos metabolism and toxicity in the earthworm Aporrectodea caliginosaScience of the Total Environment 490 (2014) 445–455. PDF: Sanchez-Hernandez et al STOTEN 2014

2015

1) Bartheld JL, Gaitán-Espitia JD, Artacho P, Salgado-Luarte C, Gianoli E & Nespolo R (2015) Energy expenditure and body size are targets of natural selection across a wide geographic range, in a terrestrial invertebrate. Functional Ecology 29: 1463–1474. PDF

2) Bozinovic F &  Portner H-O (2015) Physiological ecology meets climate change. Ecology and Evolution. doi: 10.1002/ece3.1403. PDF: Bozinovic_et_al-2015-Ecology_and_Evolution

3) Bozinovic F &  DE Naya (2015) Linking physiology, climate and species distributional ranges. In: Martin, L.B., Ghalambor, C.K., and A. Woods (eds.). Chapter 17, pp: 277-290. Integrative Organismal Biology. John Wiley & Sons, Inc., New York, 344 pp.

4) Castellanos-Frías E, García-Perea R, Gisbert J, Bozinovic F & Virgós E (2015) Intraspecific variation in the energetics of the Cabrera vole. Comp Biochem Physiol A Mol Integr Physiol. 190:32-8. PDF

5) Cortés V, Amigo L, Zanlungo S, Galgani J, Robledo F, Arrese M, Bozinovic F & Nervi F (2015) Metabolic effects of cholecystectomy: gallbladder ablation increases basal metabolic rate through G-protein coupled bile acid receptor Gpbar1-dependent mechanisms in mice. PLoS One. 10(3):e0118478. PDF

6) Inestrosa N, Ríos JA, Cisternas P, Tapia-Rojas C, Rivera DS, Braidy N, Zolezzi JM, Godoy JA, Carvajal FJ, Ardiles AO, Bozinovic F, Palacios AG & Sachdev PS (2015) Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer’s Disease. Brain Pathology. doi:10.1111/bpa.12226. PDF: Inestrosa et al. 2015 (1)

7) Narvaez C, Ramirez-Otarola N, Bozinovic F, Sanchez-Hernandez JC & Sabat P (2015) Comparative intestinal esterases amongst passerine species: Assessing vulnerability to toxic chemicals in a phylogenetically explicit context. Chemosphere. 135:75-82. PDF

8) Nespolo RF, Silva AX, Figueroa CC & Bacigalupe LD (2015) Anticipatory gene regulation driven by maternal effects in an insect–host system. Ecology and Evolution 5: 5601–5608. PDF

9) Newsome SD, Sabat P, Wolf N, Rader JA & Martinez del Rio C (2015) Multi-tissue δ2H analysis reveals altitudinal migration and tissue-specific discrimination patterns inCinclodes. Ecosphere 6(11):213. PDF

10) Rader JA, Dillon ME, Chesser RT, Sabat P & Martínez del Río C (2015) Morphological divergence in a continental adaptive radiation: South American ovenbirds of the genus Cinclodes. The Auk Ornithological Advances 132: 180–190. PDF: Rader et al. – 2014 – Morphological divergence in a continental adaptive…

11) Thienel M, Canals M, Bozinovic F & Veloso C (2015). The effects of temperature on the gas exchange cycle in Agathemera crassa. Comparative Biochemistry and Physiology, Part A. 183: 126–130. PDF: Thienel et al 2015 ciclos final

12) Vázquez DP, Gianoli E, Morris WF & Bozinovic F (2015) Ecological and evolutionary impacts of changing climatic variability. Biol Rev Camb Philos Soc. doi:1111/brv.12216 PDF

13) Ziegler L, Arim M & Bozinovic F (2015) Intraspecific scaling in frog calls: the interplay of temperature, body size and metabolic condition. Oecologia. [Epub ahead of print] PDF

2016

1) Araujo MB, Ferri-Yañez F, Bozinovic F, Chown SL & Marquet PA (2016) Erratum to Araujo et al (2013). Ecology Letters 19: 591–592. doi: 10.1111/ele.12597. PDF

2) Barahona-Segovia RM, Grez AA & Bozinovic F (2016) Testing the hypothesis of greater eurythermality in invasive than in native ladybird species: from physiological performance to life-history strategies. Ecological Entomology 41: 182–191. PDF

3) Boher F, Trefault N, Estay SA & Bozinovic F (2016) Ectotherms in Variable Thermal Landscapes: A Physiological Evaluation of the Invasive  Potential of Fruit Flies Species. Frontiers in Physiology 7:302. doi: 10.3389/fphys.2016.00302. PDF

4) Bozinovic F, Medina NR, Alruiz JM, Cavieres G, Sabat P (2016) Thermal tolerance and survival responses to scenarios of experimental climatic change: changing thermal variability reduces the heat and cold tolerance in a fly. J Comp Physiol B. [Epub ahead of print] PDF

5) Bozinovic F, Sabat P, Rezende EL & Canals M (2016) Temperature variability and thermal performance in ectotherms: acclimation, behaviour, and experimental considerations. Evolutionary Ecology Research 17: 111–124. PDF

6) Cavieres G, Bogdanovich JM & Bozinovic F (2016) Ontogenetic thermal tolerance and performance of ectotherms at variable temperatures. Journal of Evolutionary Biology. doi: 10.1111/jeb.12886 PDF

7) Clavijo-Baquet S, Cumplido N & Bozinovic F (2016) Resting Metabolic Rate Is Positively Correlated with Parental Care Behavior in a Dwarf Hamster. J Exp Zool A Ecol Genet Physiol. 325 (4):274-82. PDF

8) Cortes PA, Puschel H, Acuña P, Bartheld JL & Bozinovic F (2016) Thermal ecological physiology of native and invasive frog species: do invaders perform better? Conservation Physiology 4(1): cow056. doi:10.1093/conphys/cow056. PDF

9) Hadj-Moussa H, Moggridge JA, Luu BE, Quintero-Galvis JF, Gaitán-Espitia JD, Nespolo RF & Storey KB (2016).The hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns. Scientific Reports 6: 24627. doi: 10.1038/srep24627. PDF

10) Labra FA, Bogdanovich JM & Bozinovic F. (2016) Nonlinear temperature effects on multifractal complexity of metabolic rate of ice. PeerJ 4:e2607 https://doi.org/10.7717/peerj.2607. PDF

11) Maldonado K, Sabat P, Piriz G, Bogdanovich JM, Nespolo RF & Bozinovic F (2016) Is maximum food intake in endotherms constrained by net or factorial aerobic scope? lessons from the leaf-eared mouse. Frontiers in Physiology 7:649. doi: 10.3389/fphys.2016.00649. PDF

12) Nespolo RF, Figueroa J & Solano-Iguaran JJ (2016) Studying the evolutionary significance of thermal adaptation in ectotherms: The diversification of amphibians’ energetics. Journal of Thermal Biology 68: 5-13. http://dx.doi.org/10.1016/j.jtherbio.2016.11.014. PDF

13) Paleo-López R, Quintero-Galvis JF, Solano-Iguaran JJ, Sanchez-Salazar AM, Gaitan-Espitia JD & Nespolo RF (2016). A phylogenetic analysis of macroevolutionary patterns in fermentative yeasts. Ecology and Evolution 6: 3851–3861. doi:10.1002/ece3.2097. PDF

14) Peña-Villalobos I, Narváez C & Sabat P (2016). Metabolic cost of osmoregulation in a hypertonic environment in the invasive African clawed frog Xenopus laevis. Biology Open 5: 955-961. doi: 10.1242/bio.016543. PDF

15) Rivera DS, Lindsay C, Codocedo JF, Morel I, Pinto C, Cisternas P, Bozinovic F & Inestrosa NC (2016) Andrographolide recovers cognitive impairment in a natural model of Alzheimer’s disease. Neurobiology of Aging: 204-220. http://dx.doi.org/10.1016/j.neurobiolaging.2016.06.021.

16) Rivera DS, Inestrosa NC, Bozinovic F (2016) On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae). Biological Research. 49:10. PDF

17) Tirado C, Cortes A, Carretero MA & Bozinovic F (2016) Does the presence of livestock alter the trophic behaviour of sympatric populations of wild camelids Vicugna vicugna Molina 1782 and Lama guanicoe Müller 1976 (Artiodactyla: Camelidae)? Evidence from Central Andes. Gayana 80(1): 29-39. PDF

2017

1) Franco M, Contreras C, Place NJ, Bozinovic F & Nespolo RF (2017) Leptin levels, seasonality and thermal acclimation in the Microbiotherid marsupial : Does photoperiod play a role?. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 203: 233-240. http://dx.doi.org/10.1016/j.cbpa.2016.09.025. PDF

2) Maldonado K, Bozinovic F, Newsome SD & Sabat P (2017) Testing the niche variation hypothesis in a community of passerine birds. Ecology 98(4): 903–908. PDF

3) Negrete P, Sallaberry M, Barceló G, Maldonado K, Perona F, McGill R, Quillfeldt P & Sabat P (2017) Temporal variation in isotopic composition of Pygoscelis penguins at Ardley Island, Antarctic: Are foraging habits impacted by environmental change? Polar Biology 40:903–916. https://doi.org/10.1007/s00300-016-2017-8. PDF

4) Nespolo RF, Solano-Iguaran JJ & Bozinovic F. (2017). Phylogenetic Analysis Supports the Aerobic-Capacity Model for the Evolution of Endothermy. American Naturalist 189: 13–27. DOI: 10.1086/689598. PDF

5) Rader JA, Newsome SD, Sabat P, Chesser RT, Dillon ME & Martínez del Rio C. (2017), Isotopic niches support the resource breadth hypothesis. Journal of Animal Ecology, 86: 405–413. doi: 10.1111/1365-2656.12629. PDF

6) Zamorano J, Bozinovic F & Veloso C (2017) Colder is better: The differential effects of thermal acclimation on life history parameters in a parasitoid fly. Journal of Thermal Biology. 68: 1-4. http://dx.doi.org/10.1016/j.jtherbio.2017.03.011. PDF